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17/08/2017 Sovicell recruiting application scientist. 22/03/20173B Pharmaceuticals and Sovicell introduce a novel service offering for plasma protein binding analysis

Science & Technology


  • The binding of advanced glycation end products to cell surfaces can be measured using bead-reconstituted cellular membrane proteins.
    Schmitt, A., Nöller, J., Schmitt, J.
    Biochim Biophys Acta. 1768 (6, 2007) 1389-1399
  • ADME related profiling in 96 and 384 well plate format- A novel and robust HT-assay for the determination of lipophilicity and serum albumin binding.
    Hartmann, T., Schmitt, J., Röhring, C., Nimptsch, D., Nöller, J., Mohr, C.
    Current Drug Delivery 3 (2006) 181-192
  • From Early Drug Discovery to Clinical Trials
    Nöller, J., Schmitt, J., Hartmann, T., Löffler, T
    Screening: Trends in Drug Discovery Vol. 6 (3, 2005) 48-49
  • Just Married – in vitro and in silico ADME Prediction
    Nöller, J., Schmitt, J., Hartmann, T.
    Screening: Trends in Drug Discovery Vol. 6 (1, 2005) 32-33
  • Role of lipophilicity and protein binding in ADME prediction
    Nöller, J., Schmitt, J. Machamer, J.
    Drug Plus International (Nov. 2005) 1-3
  • Characterization of advanced glycation end products for biochemical studies: Side chain modifications and fluorescence characteristics.
    Schmitt, A, Schmitt, J, Münch, G, Gasic-Milenkovic, J
    Anal. Biochem. 338 (2005) 201-215
  • Characterization of advanced glycation end products: Mass changes in correlation to side chain modifications.
    Schmitt, A, Gasic-Milenkovic, J, Schmitt, J
    Anal. Biochem., 346 (2005) 101–106
  • Two analytical methods to study the interaction of AGEs with cell surface proteins.
    Schmitt A., Meiners I., Schmitt J., Nöller J., Ihling Ch., Sinz, A., Münch G., Nieber, K.
    J. Biochem. Biophys. Meth. 65 (2005) 121-36
  • Lipophilicity- beyond octanol/water: a comparison of modern technologies
    Hartmann T. and Schmitt J.
    Drug Discovery Today: Technologies 1 (4, 2004) 431-439
  • Multilamellar liposomes and solid-supported lipid membranes (TRANSIL): Screening of lipid-water partitioning towards a high-throughput scale
    Loidl-Stahlofen A., Hartmann T., Schöttner M., Röhring C., Brodowsky, H., Schmitt, J., Keldenich, J.
    Pharm. Res. 18 (12, 2001) 1782-1788
  • Polymer Cushions in Supported Phospholipid Bilayers Reduce Significantly the Frictional Drag between Bilayer and Solid Surface
    Schmitt J., Danner B., Bayerl T.M.
    Langmuir, 17 (2001) 244-246
  • Solid-Supported Biomolecules on Modified Silica Surfaces – A tool for fast physicochemical characterization and High-Throughput Screening
    Loidl-Stahlofen A., Schmitt, J., Nöller J., Hartmann T., Brodowsky, H., Schmitt W., Keldenich, J.
    Adv. Materials, 13 (23, 2001) 1829-1834
  • Solid-Supported Lipid Membranes as a Tool for Determination of Membrane Affinity: High-Througput Screening of a Physicochemical Parameter
    Loidl-Stahlofen A., Eckert A., Hartmann T., Schöttner M.
    J. Pharm. Sci. 90 (2001) 599-606
  • A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans
    Willmann, S.; Schmitt, W.; Keldenich, J.; Lippert, J.; Dressman, J.B.
    J. Med. Chem. 47 (16, 2004) 4022-4032
  • Physiology-based pharmacokinetic modelling: ready to be used
    Schmitt W. and Willmann S.
    Drug Discovery Today: Technologies 1 (4, 2004) 449-456
  • High-Throughput Determination of the Free Fraction of Drugs strongly Bound to Plasma Proteins
    Schuhmacher J., Kohlsdorfer C., Bühner K., Brandenburger T., Kruk R. J.
    Pharm. Sci. 93 (2004) 816-830
  • Boriss H (2010) Brain Availability is the Key Parameter for Optimizing Permeability of CNS Drugs. Drug Discovery 7:57-60.
  • Longhi, R.; Corbioli, S.; Fontana, S.; Vinco, F.; Braggio, S.; Helmdach, L.; Schiller, J.; Boriss, H. (2011) Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug Metabolism and Disposition. 39(2):312-3.21
  • Read KD, Braggio S (2010) Assesing brain free fraction in early drug discovery. Expert Opin. Drug Metab. Toxicol. 6(3):337-344
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